Q-omics provides the consensus-scored HOXB-AS4 profile across patient tissues and cancer cell-line models. HOXB-AS4 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, HOXB-AS4 is differentially expressed in 14, with the highest sampling consensus in STAD. Additionally, HOXB-AS4 RNA expression shows 13,635 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight KIRC, STAD, and KIRP as cancer lineages where HOXB-AS4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HOXB-AS4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HOXB-AS4 survival associations across molecular data types. HOXB-AS4 RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HOXB-AS4 RNA expression–survival associations across cancer types. High HOXB-AS4 expression shows unfavorable associations in KIRC, THYM, UCEC, LGG and PAAD, but favorable associations in COAD. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for HOXB-AS4 RNA expression.
This table summarizes HOXB-AS4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for HOXB-AS4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HOXB-AS4 shows higher tumor expression in STAD, HNSC, LUSC, LUAD, BRCA and ESCA. The STAD box plot shows higher HOXB-AS4 RNA expression in tumor versus normal tissue (log2 FC = +1.932, t-test p < 0.001).
This table shows molecular features associated with HOXB-AS4 in patient tissues and cancer cell lines. In patient samples, HOXB-AS4 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set.
