HOXB-AS4

Across TCGA pan-cancer cohorts, HOXB-AS4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HOXB-AS4’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where HOXB-AS4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXB-AS4 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

STAD, HNSC, and LUSC are the cancer types where HOXB-AS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXB-AS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Female	All	+1.932	<.001	10	view →
HNSC	Male	II,III,IV	+1.169	<.001	10	view →
LUSC	Male	All	+0.785	<.001	4	view →
LUAD	All	All	+0.374	<.001	4	view →
BRCA	Female	All	+0.232	.001	4	view →
ESCA	All	All	+1.738	.018	3	view →
KIRP	All	IV	+1.722	.004	3	view →
BLCA	All	III,IV	+0.976	.020	3	view →
KIRC	All	All	−0.420	.005	3	view →
PAAD	All	All	+1.785	.008	2	view →
COAD	Female	All	−0.914	.010	2	view →
UCEC	All	All	+0.526	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HOXB-AS4–STAD

Open the STAD breakdown →