HOXA6

Across TCGA patient cohorts, HOXA6 mutation is significantly associated with the RNA expression of many other genes, with 1,974 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXA6-associated genes across cancer lineages are RNA5SP143, RNU6-91P, and OR4D11. Each is linked with HOXA6 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXA6-to-partner and partner-to-HOXA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP143 grouped by HOXA6-low versus HOXA6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA6→partner) and Y-score (partner→HOXA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP143 →	+0.208	+5.272	<.001	.001	3	3
LIHC	RNU6-91P →	+0.257	+5.317	<.001	.002	3	2
LIHC	OR4D11 →	+0.029	+5.584	<.001	.001	3	2
LIHC	MIR4694 →	+0.265	+4.894	<.001	.004	3	2
LUAD	RNU6-1082P →	+0.520	+4.882	<.001	<.001	3	2
LUAD	RN7SKP12 →	+0.521	+3.514	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,974 associations by consensus.

RNA5SP143 by HOXA6 expression — LUSC

Explore this box plot interactively →