HOXA6

Across TCGA pan-cancer cohorts, HOXA6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HOXA6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HOXA6 RNA is repressed in tumor relative to normal tissue. In most cancer types HOXA6 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where HOXA6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXA6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.658	<.001	11	view →
THCA	All	II,III,IV	−0.124	<.001	9	view →
HNSC	Male	All	+0.636	<.001	8	view →
BRCA	All	All	−1.749	<.001	6	view →
PAAD	Female	All	+1.515	.022	4	view →
CHOL	All	II,III,IV	+1.484	<.001	4	view →
COAD	Female	II,III,IV	−0.603	.023	3	view →
LIHC	All	All	+0.147	.004	3	view →
KIRP	All	IV	+1.154	.043	2	view →
KICH	All	All	−0.852	.010	2	view →
BLCA	All	All	+0.595	.048	2	view →
STAD	Male	II,III,IV	+0.607	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HOXA6–KIRC

Open the KIRC breakdown →