HOXA11

Across TCGA patient cohorts, HOXA11 mutation is significantly associated with the RNA expression of many other genes, with 2,163 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXA11-associated genes across cancer lineages are RN7SL554P, MIR4759, and RNU6-23P. Each is linked with HOXA11 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA11-to-partner and partner-to-HOXA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL554P grouped by HOXA11-low versus HOXA11-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA11→partner) and Y-score (partner→HOXA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL554P →	+0.170	+5.473	.005	.005	3	2
BLCA	MIR4759 →	+0.245	+4.859	<.001	.004	3	2
UCEC	RNU6-23P →	+0.298	+1.967	<.001	.005	3	2
LUSC	RNU1-1 →	+0.423	+4.781	<.001	.003	3	2
UCEC	RNA5SP369 →	+0.388	+2.193	<.001	.002	3	2
LUSC	SMC4P1 →	+0.084	+4.548	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,163 associations by consensus.

RN7SL554P by HOXA11 expression — BRCA

Explore this box plot interactively →