HOXA11

Across TCGA pan-cancer cohorts, HOXA11 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HOXA11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HOXA11 RNA is repressed in tumor relative to normal tissue. In most cancer types HOXA11 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where HOXA11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXA11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.340	<.001	12	view →
HNSC	Male	All	+1.096	<.001	11	view →
COAD	Female	II,III,IV	+1.158	<.001	9	view →
STAD	Male	II,III,IV	+2.187	<.001	8	view →
LUAD	All	II,III,IV	+0.654	<.001	8	view →
LUSC	Male	All	+1.301	<.001	6	view →
THCA	All	III,IV	+0.194	<.001	6	view →
PAAD	Female	All	+1.650	<.001	4	view →
BRCA	Female	II,III,IV	+0.388	<.001	4	view →
BLCA	Male	IV	−1.822	.025	2	view →
LIHC	All	All	+0.263	.015	2	view →
ESCA	All	All	+1.511	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HOXA11–KIRC

Open the KIRC breakdown →