HOXA10-AS

Across TCGA pan-cancer cohorts, HOXA10-AS RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HOXA10-AS data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher HOXA10-AS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HOXA10-AS expression acts as an unfavorable survival marker, although some lineages such as STAD and COAD show a favorable association.

CESC, LGG, and MESO are the cancer types where HOXA10-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.425	0.646	<.001	94	view →
LGG	OS	Tertile	All	0.230	0.507	<.001	54	view →
MESO	OS	Median	II,III,IV	0.191	0.392	.002	52	view →
ACC	DFS	Quartile	II,III,IV	0.394	0.692	.004	50	view →
STAD	OS	Tertile	II,III,IV	0.745	0.616	.014	48	view →
UCEC	DFS	Tertile	All	0.850	0.928	<.001	40	view →
LAML	DFS	Tertile	All	0.300	0.629	<.001	38	view →
LUAD	OS	Quartile	All	0.594	0.724	.002	31	view →
COAD	DFS	Median	All	0.660	0.391	.004	29	view →
KIRP	OS	Median	All	0.979	0.912	.008	15	view →
READ	DFS	Quartile	IV	0.359	0.767	.008	13	view →
UCS	DFS	Tertile	IV	0.956	0.312	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HOXA10-AS–CESC (DFS)

Open the CESC breakdown →