HOXA10-AS

Across TCGA pan-cancer cohorts, HOXA10-AS RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HOXA10-AS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXA10-AS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXA10-AS is over-expressed in tumor, although a few such as BRCA and BLCA show the opposite, repressed pattern.

HNSC, STAD, and LUAD are the cancer types where HOXA10-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXA10-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.950	<.001	12	view →
STAD	Male	II,III,IV	+1.168	<.001	9	view →
LUAD	All	All	+0.262	<.001	8	view →
UCEC	All	II,III,IV	+1.759	<.001	6	view →
KIRP	Male	II,III,IV	+0.926	.002	6	view →
LUSC	All	All	+0.739	<.001	6	view →
BRCA	All	III,IV	−0.576	<.001	6	view →
BLCA	Male	IV	−1.307	.021	2	view →
PRAD	All	All	+0.546	<.001	2	view →
KICH	Female	III,IV	+0.486	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HOXA10-AS–HNSC

Open the HNSC breakdown →