Q-omics provides the consensus-scored HOXA-AS2 profile across patient tissues and cancer cell-line models. HOXA-AS2 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, HOXA-AS2 is differentially expressed in 10, with the highest sampling consensus in KICH. Additionally, HOXA-AS2 RNA expression shows 16,997 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight KIRC, KICH, and KIRP as cancer lineages where HOXA-AS2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HOXA-AS2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HOXA-AS2 survival associations across molecular data types. HOXA-AS2 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HOXA-AS2 RNA expression–survival associations across cancer types. High HOXA-AS2 expression shows unfavorable associations in KIRC, ACC, LGG, COAD and LAML, but favorable associations in SKCM. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KIRC as the clearest survival context for HOXA-AS2 RNA expression.
This table summarizes HOXA-AS2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for HOXA-AS2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HOXA-AS2 shows lower tumor expression in KICH, LUAD, BRCA and LUSC and higher tumor expression in LIHC and KIRP. The KICH box plot shows higher HOXA-AS2 RNA expression in normal versus tumor tissue (log2 FC = −2.659, t-test p < 0.001).
This table shows molecular features associated with HOXA-AS2 in patient tissues and cancer cell lines. In patient samples, HOXA-AS2 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set.
