HOXA-AS2

Across TCGA pan-cancer cohorts, HOXA-AS2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HOXA-AS2 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HOXA-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HOXA-AS2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CHOL show a favorable association.

KIRC, ACC, and LGG are the cancer types where HOXA-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.533	0.713	.001	73	view →
ACC	OS	Tertile	III,IV	0.306	0.895	.001	59	view →
LGG	DFS	Median	All	0.622	0.818	<.001	52	view →
COAD	DFS	Tertile	All	0.382	0.616	<.001	50	view →
SKCM	OS	Tertile	All	0.437	0.231	<.001	46	view →
LAML	DFS	Quartile	All	0.295	0.661	<.001	34	view →
CHOL	DFS	Tertile	II,III,IV	0.725	0.122	.005	30	view →
THCA	OS	Tertile	All	0.975	0.999	.006	27	view →
UCEC	OS	Quartile	All	0.890	0.964	.001	22	view →
UVM	DFS	Tertile	III,IV	0.364	0.728	.016	18	view →
CESC	OS	Median	III,IV	0.643	0.837	.017	12	view →
READ	DFS	Tertile	IV	0.364	0.691	.016	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HOXA-AS2–KIRC (DFS)

Open the KIRC breakdown →