HOTTIP

Across TCGA patient cohorts, HOTTIP RNA expression is significantly associated with the go_rna of many other GO terms, with 7,033 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible HOTTIP-associated GO terms across cancer lineages are Proximal/distal pattern formation, Embryonic forelimb morphogenesis, and Positive regulation of cell cycle process. Each is linked with HOTTIP in more than 14 cancer types. Because this analysis shows association rather than direction, both HOTTIP-to-partner and partner-to-HOTTIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proximal/distal pattern formation grouped by HOTTIP-low versus HOTTIP-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOTTIP→partner) and Y-score (partner→HOTTIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Proximal/distal pattern formation →	+0.056	+0.788	<.001	<.001	3	15
TGCT	Embryonic forelimb morphogenesis →	+0.059	+0.661	<.001	<.001	3	15
KIRC	Positive regulation of cell cycle process →	+0.032	+0.103	<.001	<.001	3	14
TGCT	Forelimb morphogenesis →	+0.044	+0.627	<.001	<.001	3	14
TGCT	Embryonic skeletal joint development →	+0.081	+0.575	<.001	<.001	3	13
TGCT	Urogenital system development →	+0.047	+0.649	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,033 associations by consensus.

Proximal/distal pattern formation by HOTTIP expression — TGCT

Explore this box plot interactively →