HOTTIP

Across TCGA pan-cancer cohorts, HOTTIP RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HOTTIP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOTTIP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOTTIP is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

HNSC, STAD, and LIHC are the cancer types where HOTTIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOTTIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.103	<.001	8	view →
STAD	Male	All	+1.258	<.001	6	view →
LIHC	Male	All	+0.803	<.001	6	view →
BLCA	Male	III,IV	−1.525	.002	5	view →
LUSC	All	All	+0.190	.004	5	view →
UCEC	All	IV	+1.255	.024	2	view →
KIRP	All	All	+0.137	.011	2	view →
KIRC	Male	All	+0.036	.042	2	view →
COAD	Female	III,IV	−1.516	.029	1	view →
CHOL	All	All	+0.266	.026	1	view →
LUAD	All	All	+0.029	.040	1	view →
THCA	Female	II,III,IV	−0.007	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HOTTIP–HNSC

Open the HNSC breakdown →