HOTTIP

Across TCGA pan-cancer cohorts, HOTTIP RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HOTTIP data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HOTTIP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOTTIP expression acts as an unfavorable survival marker, although some lineages such as COAD and READ show a favorable association.

KIRC, HNSC, and UVM are the cancer types where HOTTIP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.505	0.716	<.001	162	view →
HNSC	OS	Tertile	II,III,IV	0.549	0.722	<.001	110	view →
UVM	OS	Tertile	All	0.637	0.972	<.001	81	view →
MESO	DFS	Tertile	All	0.256	0.419	.009	62	view →
COAD	DFS	Tertile	II,III,IV	0.729	0.552	.002	62	view →
SKCM	OS	Quartile	III,IV	0.445	0.763	<.001	42	view →
ACC	DFS	Tertile	All	0.184	0.740	<.001	37	view →
LUAD	DFS	Median	II,III,IV	0.396	0.643	.003	24	view →
TGCT	DFS	Tertile	All	0.665	0.875	.005	18	view →
LAML	DFS	Quartile	All	0.191	0.597	.006	18	view →
READ	OS	Tertile	All	0.861	0.470	.009	16	view →
ESCA	OS	Median	All	0.563	1.000	.003	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HOTTIP–KIRC (OS)

Open the KIRC breakdown →