HOPX

Across TCGA patient cohorts, HOPX protein abundance is significantly associated with the RNA expression of many other genes, with 14,862 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HOPX-associated genes across cancer lineages are TIMP3, ZCCHC24, and SRPX. Each is linked with HOPX in more than 8 cancer types. Because this analysis shows association rather than direction, both HOPX-to-partner and partner-to-HOPX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOPX versus TIMP3 in OV, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOPX→partner) and Y-score (partner→HOPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TIMP3 →	+1.635	+0.685	<.001	<.001	3	9
BRCA	ZCCHC24 →	+1.146	+0.594	<.001	<.001	3	9
GBM	SRPX →	+1.128	+0.600	.001	.004	3	8
OV	COMP →	+2.337	+0.943	<.001	<.001	3	8
OV	EFEMP1 →	+1.549	+0.683	<.001	<.001	3	8
UCEC	RECK →	+0.891	+1.310	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,862 associations by consensus.

HOPX vs TIMP3 — OV

Explore this scatter interactively →