HOPX

Across TCGA patient cohorts, HOPX mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOPX-associated genes across cancer lineages are MEK1, Notch1, and PDK1_pS241. Each is linked with HOPX in more than 1 cancer types. Because this analysis shows association rather than direction, both HOPX-to-partner and partner-to-HOPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by HOPX-low versus HOPX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOPX→partner) and Y-score (partner→HOPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.401	+3.169	.045	.020	3	1
UCEC	Notch1 →	+0.208	+3.169	.007	.020	3	1
UCEC	PDK1_pS241 →	+0.189	+3.000	.044	.036	3	1
UCEC	VHL →	-1.028	-3.169	.005	.019	3	1
UCEC	4E-BP1 →	+0.437	+2.837	.003	.035	3	1
UCEC	EGFR_pY1068 →	-0.332	-3.169	.015	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by HOPX expression — UCEC

Explore this box plot interactively →