HOPX

Across TCGA cell cohorts, HOPX RNA expression is significantly associated with the go_rna of many other GO terms, with 2,530 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HOPX-associated GO terms across cancer lineages are Trophectodermal cell differentiation, Skin morphogenesis, and Positive regulation of release of sequestered calcium ion into cytosol. Each is linked with HOPX in more than 9 cancer types. Because this analysis shows association rather than direction, both HOPX-to-partner and partner-to-HOPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Trophectodermal cell differentiation grouped by HOPX-low versus HOPX-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOPX→partner) and Y-score (partner→HOPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Trophectodermal cell differentiation →	-0.230	-1.555	<.001	.002	2	10
SKIN	Skin morphogenesis →	+0.087	+0.390	.002	.008	3	7
SKIN	Positive regulation of release of sequestered calcium ion into cytosol →	-0.170	-0.312	<.001	.007	3	6
LUNG_NSCLC_LUAD	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.074	+1.956	.001	.006	3	6
URINARY_TRACT	Cellular response to steroid hormone stimulus →	+0.058	+1.676	.007	.007	3	6
BONE	Intraciliary transport →	-0.064	-1.169	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,530 associations by consensus.

Trophectodermal cell differentiation by HOPX expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →