HNRNPU

Across TCGA patient cohorts, HNRNPU mutation is significantly associated with the RNA expression of many other genes, with 2,135 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPU-associated genes across cancer lineages are RN7SL248P, CYCSP49, and RN7SL83P. Each is linked with HNRNPU in more than 2 cancer types. Because this analysis shows association rather than direction, both HNRNPU-to-partner and partner-to-HNRNPU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by HNRNPU-low versus HNRNPU-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPU→partner) and Y-score (partner→HNRNPU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL248P →	+0.057	+4.464	<.001	.005	3	3
COAD	CYCSP49 →	+0.344	+7.727	<.001	<.001	3	2
COAD	RN7SL83P →	+0.559	+5.392	<.001	.002	3	2
HNSC	IFNNP1 →	+0.042	+4.468	<.001	.006	3	2
HNSC	KLF3P2 →	+0.117	+5.111	<.001	<.001	3	2
UCEC	DCP1A →	+0.345	+1.637	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,135 associations by consensus.

RN7SL248P by HNRNPU expression — BRCA

Explore this box plot interactively →