HNRNPR

Across TCGA patient cohorts, HNRNPR mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPR-associated genes across cancer lineages are Notch1, Cyclin-B1, and EGFR_pY1068. Each is linked with HNRNPR in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPR-to-partner and partner-to-HNRNPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by HNRNPR-low versus HNRNPR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPR→partner) and Y-score (partner→HNRNPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.247	+3.183	<.001	.009	3	2
UCEC	Cyclin-B1 →	+0.756	+3.169	.003	.019	3	2
UCEC	EGFR_pY1068 →	-0.379	-3.321	.001	.010	3	1
UCEC	FoxM1 →	+0.364	+3.009	.002	.019	3	1
UCEC	Gab2 →	+0.486	+3.000	.003	.036	3	1
UCEC	JNK2 →	+0.284	+2.584	.002	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Notch1 by HNRNPR expression — UCEC

Explore this box plot interactively →