HNRNPR

Across TCGA pan-cancer cohorts, HNRNPR RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HNRNPR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HNRNPR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HNRNPR is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where HNRNPR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HNRNPR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.794	<.001	12	view →
BLCA	Male	All	+0.716	<.001	11	view →
LIHC	Female	II,III,IV	+1.173	<.001	9	view →
STAD	Male	II,III,IV	+0.933	<.001	8	view →
LUSC	Male	II,III,IV	+0.782	<.001	7	view →
THCA	All	All	−0.367	<.001	7	view →
KICH	Female	All	−1.315	<.001	6	view →
BRCA	All	II,III,IV	+0.375	<.001	6	view →
CHOL	Male	All	+1.933	<.001	5	view →
LUAD	Male	II,III,IV	+0.690	<.001	4	view →
COAD	Male	All	+0.441	<.001	4	view →
KIRC	All	II,III,IV	−0.222	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HNRNPR–HNSC

Open the HNSC breakdown →