HNRNPR

Across TCGA pan-cancer cohorts, HNRNPR RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HNRNPR data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HNRNPR RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HNRNPR expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

ACC, KIRC, and LIHC are the cancer types where HNRNPR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.198	0.688	<.001	99	view →
KIRC	DFS	Median	All	0.771	0.488	<.001	50	view →
LIHC	OS	Tertile	All	0.581	0.808	<.001	48	view →
KIRP	DFS	Tertile	II,III,IV	0.312	0.815	.002	47	view →
SARC	OS	Median	All	0.388	0.634	<.001	39	view →
UCS	DFS	Tertile	IV	0.936	0.488	.024	36	view →
BRCA	OS	Tertile	III,IV	0.696	0.384	<.001	35	view →
LGG	DFS	Tertile	All	0.642	0.828	<.001	32	view →
KICH	OS	Median	II,III,IV	0.810	0.966	.013	28	view →
LUAD	OS	Tertile	All	0.753	0.862	.003	22	view →
LUSC	DFS	Tertile	III,IV	0.254	0.935	.002	20	view →
PAAD	OS	Quartile	All	0.301	0.594	.007	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HNRNPR–ACC (DFS)

Open the ACC breakdown →