HMGXB4

Across TCGA patient cohorts, HMGXB4 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,751 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGXB4-associated proteins across cancer lineages are PRC1_T481, SMC2, and SMC4. Each is linked with HMGXB4 in more than 7 cancer types. Because this analysis shows association rather than direction, both HMGXB4-to-partner and partner-to-HMGXB4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGXB4 versus PRC1_T481 in CCRCC, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGXB4→partner) and Y-score (partner→HMGXB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PRC1_T481 →	+1.319	+0.527	.003	.003	3	8
LSCC	SMC2 →	+0.542	+0.568	<.001	<.001	3	7
GBM	SMC4 →	+0.499	+0.364	<.001	<.001	3	7
LSCC	MCM5 →	+0.650	+0.565	<.001	<.001	3	7
HNSC	TRMT2A →	+0.366	+0.728	<.001	<.001	3	7
UCEC	NCAPG →	+0.548	+0.358	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,751 associations by consensus.

HMGXB4 vs PRC1_T481 — CCRCC

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