HMGXB4

Across TCGA pan-cancer cohorts, HMGXB4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HMGXB4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HMGXB4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGXB4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, LIHC, and BLCA are the cancer types where HMGXB4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGXB4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.931	<.001	12	view →
LIHC	Female	II,III,IV	+1.076	<.001	9	view →
BLCA	All	All	+0.595	<.001	9	view →
KIRC	All	All	+0.338	<.001	9	view →
STAD	Male	II,III,IV	+0.762	<.001	8	view →
LUAD	Male	II,III,IV	+0.579	<.001	7	view →
LUSC	Male	All	+0.938	<.001	6	view →
BRCA	All	II,III,IV	+0.338	<.001	6	view →
CHOL	Male	All	+2.283	<.001	5	view →
COAD	All	II,III,IV	+0.387	<.001	5	view →
READ	Male	All	+0.586	.047	4	view →
ESCA	All	All	+0.827	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HMGXB4–HNSC

Open the HNSC breakdown →