HMGXB3

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HMGXB3 protein abundance is significantly associated with the RNA expression of many other genes, with 3,226 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HMGXB3-associated genes across cancer lineages are PGK1, SLC38A1, and GHR. Each is linked with HMGXB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HMGXB3-to-partner and partner-to-HMGXB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGXB3 versus PGK1 in UCEC, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGXB3→partner) and Y-score (partner→HMGXB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECPGK1 →-1.191-0.416<.001<.00132
UCECSLC38A1 →-1.182-0.407<.001<.00132
BRCAGHR →+1.026+0.486.002.00132
UCECITGB6 →-0.840-0.351.006.00132
UCECSLC2A1 →-1.320-0.478<.001<.00132
UCECHMGA1 →-1.170-0.513<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,226 associations by consensus.

HMGXB3 vs PGK1 — UCEC

Per-sample scatter of HMGXB3 vs PGK1 in UCEC (Pearson r = -0.43).

Explore this scatter interactively →

Exploration