HMGXB3

Across TCGA pan-cancer cohorts, HMGXB3 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated HMGXB3 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher HMGXB3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGXB3 expression acts as an unfavorable survival marker, although some lineages such as SCLC and PAAD show a favorable association.

LIHC, HNSC, and KICH are the cancer types where HMGXB3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.440	0.641	<.001	94	view →
HNSC	OS	Tertile	All	0.414	0.726	<.001	68	view →
KICH	DFS	Median	All	0.768	1.000	.001	65	view →
LGG	DFS	Median	All	0.652	0.825	<.001	54	view →
LUSC	OS	Tertile	III,IV	0.562	0.858	<.001	50	view →
UVM	DFS	Median	All	0.337	0.614	.005	32	view →
MESO	DFS	Tertile	All	0.419	0.848	.012	24	view →
SKCM	DFS	Median	III,IV	0.144	0.438	.002	19	view →
KIRC	DFS	Quartile	IV	0.383	0.598	.028	18	view →
SARC	OS	Quartile	All	0.586	0.840	.006	17	view →
CESC	DFS	Quartile	All	0.710	0.892	<.001	12	view →
ESCA	OS	Median	III,IV	0.400	0.686	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

HMGXB3–LIHC (DFS)

Open the LIHC breakdown →