HMGCL

Across TCGA cell cohorts, HMGCL mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HMGCL-associated genes across cancer lineages are LILRA1, VCY1B, and VCY. Each is linked with HMGCL in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGCL-to-partner and partner-to-HMGCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LILRA1 grouped by HMGCL-low versus HMGCL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCL→partner) and Y-score (partner→HMGCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LILRA1 →	+0.009	+3.510	.003	.003	3	1
LARGE_INTESTINE	VCY1B →	+0.816	+3.936	<.001	.002	3	1
LARGE_INTESTINE	VCY →	+0.634	+3.994	<.001	.002	3	1
LARGE_INTESTINE	FAM205C →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GALNT17 →	+0.828	+3.987	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

LILRA1 by HMGCL expression — LARGE_INTESTINE

Explore this box plot interactively →