HMGCL

Across TCGA pan-cancer cohorts, HMGCL RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HMGCL data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HMGCL RNA is associated with better overall survival. In most high-consensus cancer types, elevated HMGCL expression acts as an unfavorable survival marker, although some lineages such as KIRP and COAD show a favorable association.

KIRP, COAD, and UCS are the cancer types where HMGCL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.767	0.621	<.001	130	view →
COAD	OS	Median	All	0.916	0.818	<.001	66	view →
UCS	OS	Tertile	III,IV	0.237	0.753	<.001	64	view →
BRCA	DFS	Quartile	III,IV	0.896	0.683	.001	57	view →
LGG	DFS	Median	All	0.300	0.495	<.001	50	view →
KIRC	DFS	Median	All	0.738	0.518	<.001	48	view →
GBM	OS	Tertile	All	0.257	0.624	<.001	27	view →
PCPG	DFS	Quartile	All	1.000	0.571	.006	24	view →
ACC	DFS	Median	All	0.278	0.755	.002	22	view →
MESO	OS	Median	All	0.470	0.303	.010	17	view →
LUSC	DFS	Quartile	II,III,IV	0.247	0.557	.001	11	view →
UCEC	DFS	Quartile	All	0.915	0.860	.027	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HMGCL–KIRP (OS)

Open the KIRP breakdown →