HMGB3P31

Across TCGA patient cohorts, HMGB3P31 RNA expression is significantly associated with the protein abundance of many other proteins, with 4,933 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HMGB3P31-associated proteins across cancer lineages are SPCS1, SRA1, and STK26. Each is linked with HMGB3P31 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGB3P31-to-partner and partner-to-HMGB3P31 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGB3P31 versus SPCS1 in OV, with a Pearson correlation of -0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB3P31→partner) and Y-score (partner→HMGB3P31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPCS1 →	-0.404	-0.457	<.001	<.001	3	2
BRCA	SRA1 →	-0.187	-0.239	.001	.002	3	2
BRCA	STK26 →	+0.293	+0.262	.009	.003	3	2
GBM	UAP1 →	-0.425	-0.220	.001	.002	3	2
OV	NEK1 →	-0.229	-0.469	.007	.008	3	2
GBM	PDIA6 →	-0.330	-0.195	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,933 associations by consensus.

HMGB3P31 vs SPCS1 — OV

Explore this scatter interactively →