HMGB3P31

Across TCGA pan-cancer cohorts, HMGB3P31 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of HMGB3P31’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where HMGB3P31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB3P31 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.

LUSC and ESCA are the cancer types where HMGB3P31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB3P31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+0.035	.019	2	view →
ESCA	All	All	−0.143	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

HMGB3P31–LUSC

Open the LUSC breakdown →