HMGB3P31

Across TCGA pan-cancer cohorts, HMGB3P31 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated HMGB3P31 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HMGB3P31 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGB3P31 expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

KIRP, UCS, and COAD are the cancer types where HMGB3P31 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	III,IV	0.162	0.711	<.001	63	view →
UCS	DFS	Tertile	III,IV	0.142	0.475	.002	36	view →
COAD	DFS	Tertile	III,IV	0.261	0.654	<.001	33	view →
MESO	OS	Tertile	II,III,IV	0.264	0.434	.028	27	view →
SKCM	OS	Tertile	IV	0.241	0.667	.007	24	view →
LIHC	OS	Tertile	All	0.628	0.799	.014	21	view →
LUAD	OS	Tertile	II,III,IV	0.508	0.174	.012	20	view →
HNSC	OS	Tertile	IV	0.652	0.752	.013	12	view →
READ	DFS	Tertile	IV	0.217	0.706	.001	9	view →
OV	OS	Tertile	All	0.867	0.832	.039	4	view →
ESCA	OS	Quartile	III,IV	0.606	0.345	.049	3	view →
ACC	DFS	Median	II,III,IV	0.181	0.566	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

HMGB3P31–KIRP (DFS)

Open the KIRP breakdown →