HMGB1P21

Across TCGA patient cohorts, HMGB1P21 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,543 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HMGB1P21-associated proteins across cancer lineages are UPP1, SNX2_S185, and MAP7D1_S460. Each is linked with HMGB1P21 in more than 4 cancer types. Because this analysis shows association rather than direction, both HMGB1P21-to-partner and partner-to-HMGB1P21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGB1P21 versus UPP1 in GBM, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P21→partner) and Y-score (partner→HMGB1P21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UPP1 →	+0.774	+0.536	.001	<.001	3	5
PDAC	SNX2_S185 →	+0.729	+0.480	.002	.002	3	4
LSCC	MAP7D1_S460 →	+0.472	+0.582	.001	<.001	3	4
LSCC	MAP7D1_S70 →	+0.479	+0.544	.001	.002	2	5
CCRCC	TGFB1 →	+0.369	+0.634	.001	.002	3	4
BRCA	ARHGAP4_S906 →	+3.016	+0.686	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,543 associations by consensus.

HMGB1P21 vs UPP1 — GBM

Explore this scatter interactively →