HMGB1P21

Across TCGA pan-cancer cohorts, HMGB1P21 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of HMGB1P21’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HMGB1P21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB1P21 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

HNSC, LUSC, and BRCA are the cancer types where HMGB1P21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB1P21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.087	.004	7	view →
LUSC	Male	III,IV	+0.400	.031	2	view →
BRCA	All	III,IV	−0.114	.030	2	view →
KIRC	All	III,IV	+0.045	.019	2	view →
LUAD	All	All	+0.176	.014	1	view →
THCA	All	All	−0.072	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

HMGB1P21–HNSC

Open the HNSC breakdown →