HMGB1P15

Across TCGA patient cohorts, HMGB1P15 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,973 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible HMGB1P15-associated GO terms across cancer lineages are Positive regulation of cell cycle phase transition, RNA methylation, and mRNA transport. Each is linked with HMGB1P15 in more than 7 cancer types. Because this analysis shows association rather than direction, both HMGB1P15-to-partner and partner-to-HMGB1P15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell cycle phase transition grouped by HMGB1P15-low versus HMGB1P15-high in UCEC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P15→partner) and Y-score (partner→HMGB1P15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Positive regulation of cell cycle phase transition →	+0.042	+0.024	<.001	.003	2	8
KIRP	RNA methylation →	+0.037	+0.017	<.001	.002	2	8
KIRP	mRNA transport →	+0.055	+0.014	<.001	.001	3	7
KIRP	RNA localization →	+0.050	+0.028	<.001	<.001	3	7
ESCA	Positive regulation of mitotic cell cycle phase transition →	+0.048	+0.070	<.001	.006	2	7
KIRP	Regulation of double-strand break repair via homologous recombination →	+0.037	+0.018	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,973 associations by consensus.

Positive regulation of cell cycle phase transition by HMGB1P15 expression — UCEC

Explore this box plot interactively →