HMGB1P15

Across TCGA pan-cancer cohorts, HMGB1P15 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated HMGB1P15 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HMGB1P15 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGB1P15 expression acts as an unfavorable survival marker, although some lineages such as LUAD and ESCA show a favorable association.

UCEC, STAD, and BRCA are the cancer types where HMGB1P15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.645	0.849	<.001	102	view →
STAD	DFS	Median	II,III,IV	0.305	0.602	.009	37	view →
BRCA	DFS	Tertile	All	0.140	1.000	.001	36	view →
READ	OS	Tertile	IV	0.077	1.000	.014	33	view →
BLCA	OS	Tertile	IV	0.276	0.627	.004	24	view →
LIHC	OS	Tertile	II,III,IV	0.136	0.621	.006	18	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	15	view →
PAAD	OS	Tertile	II,III,IV	0.196	0.508	.039	9	view →
LGG	DFS	Tertile	All	0.614	0.752	.019	9	view →
LUAD	OS	Tertile	All	0.878	0.326	.019	9	view →
ESCA	OS	Quartile	II,III,IV	0.881	0.675	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HMGB1P15–UCEC (DFS)

Open the UCEC breakdown →