HMGB1P15

RNA — tumor vs normal
Tumor vs NormalRNABox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, HMGB1P15 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of HMGB1P15’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where HMGB1P15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB1P15 is over-expressed in tumor.

BLCA and HNSC are the cancer types where HMGB1P15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB1P15 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.
LineageGenderStageFold-changepSampling consensus
BLCAAllAll+0.060.0213view →
HNSCAllIII,IV+0.040.0102view →
Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

HMGB1P15–BLCA

Tumor-vs-normal expression box plot for HMGB1P15 RNA in BLCA.

Open the BLCA breakdown →

Exploration