HMG20B

Across TCGA patient cohorts, HMG20B mutation is significantly associated with the RNA expression of many other genes, with 424 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMG20B-associated genes across cancer lineages are RNU6-650P, HSPE1P12, and RN7SKP2. Each is linked with HMG20B in more than 1 cancer types. Because this analysis shows association rather than direction, both HMG20B-to-partner and partner-to-HMG20B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-650P grouped by HMG20B-low versus HMG20B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMG20B→partner) and Y-score (partner→HMG20B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-650P →	+0.419	+5.038	<.001	.009	3	2
CESC	HSPE1P12 →	+0.103	+4.342	<.001	.007	3	2
BLCA	RN7SKP2 →	+0.179	+6.618	<.001	.001	3	2
UCEC	RPL22P14 →	+0.139	+2.525	<.001	.004	3	2
UCEC	TRG-AS1 →	+0.423	+3.499	.001	.002	3	1
BRCA	RNU6-278P →	+0.552	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 424 associations by consensus.

RNU6-650P by HMG20B expression — BLCA

Explore this box plot interactively →