HMG20B

Across TCGA pan-cancer cohorts, HMG20B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HMG20B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HMG20B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMG20B is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LIHC, and COAD are the cancer types where HMG20B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMG20B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.326	<.001	9	view →
LIHC	Female	II,III,IV	+1.059	<.001	9	view →
COAD	Male	III,IV	+0.769	<.001	9	view →
KIRC	Male	III,IV	+0.334	.001	7	view →
LUSC	All	II,III,IV	+0.742	<.001	6	view →
BRCA	All	All	+0.610	<.001	6	view →
LUAD	All	III,IV	+0.339	.007	6	view →
KICH	Female	All	−0.730	<.001	5	view →
STAD	All	II,III,IV	+0.480	.004	4	view →
CHOL	Male	All	+1.958	<.001	3	view →
BLCA	All	All	+0.357	.015	3	view →
PRAD	All	All	+0.674	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HMG20B–HNSC

Open the HNSC breakdown →