HMBS

Across TCGA patient cohorts, HMBS RNA expression is significantly associated with the protein abundance of many other proteins, with 17,329 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMBS-associated proteins across cancer lineages are WDHD1, RFC4, and RRM2. Each is linked with HMBS in more than 7 cancer types. Because this analysis shows association rather than direction, both HMBS-to-partner and partner-to-HMBS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMBS versus WDHD1 in LSCC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMBS→partner) and Y-score (partner→HMBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDHD1 →	+0.685	+0.516	<.001	<.001	3	8
GBM	RFC4 →	+0.449	+0.398	<.001	<.001	3	8
UCEC	RRM2 →	+0.902	+0.814	<.001	<.001	3	8
UCEC	SMC2 →	+0.703	+0.845	<.001	<.001	3	8
UCEC	MCM4 →	+0.760	+0.701	<.001	<.001	3	8
LSCC	MKI67 →	+0.629	+0.632	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,329 associations by consensus.

HMBS vs WDHD1 — LSCC

Explore this scatter interactively →