HMBS

Across TCGA pan-cancer cohorts, HMBS RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HMBS’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where HMBS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMBS is over-expressed in tumor.

BLCA, COAD, and HNSC are the cancer types where HMBS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMBS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.159	<.001	11	view →
COAD	Female	II,III,IV	+1.210	<.001	10	view →
HNSC	Male	III,IV	+0.776	<.001	10	view →
LIHC	Female	II,III,IV	+1.196	<.001	9	view →
STAD	Male	II,III,IV	+1.150	<.001	9	view →
LUAD	All	III,IV	+1.144	<.001	9	view →
LUSC	Male	II,III,IV	+1.303	<.001	8	view →
KIRP	All	All	+0.515	<.001	8	view →
UCEC	All	III,IV	+1.383	<.001	6	view →
BRCA	All	All	+0.438	<.001	6	view →
CHOL	All	All	+1.175	<.001	5	view →
PRAD	All	All	+0.344	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HMBS–BLCA

Open the BLCA breakdown →