HMBOX1-IT1

Across TCGA patient cohorts, HMBOX1-IT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,979 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible HMBOX1-IT1-associated GO terms across cancer lineages are Regulation of telomere maintenance, Negative regulation of mRNA metabolic process, and Regulation of mRNA processing. Each is linked with HMBOX1-IT1 in more than 12 cancer types. Because this analysis shows association rather than direction, both HMBOX1-IT1-to-partner and partner-to-HMBOX1-IT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomere maintenance grouped by HMBOX1-IT1-low versus HMBOX1-IT1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMBOX1-IT1→partner) and Y-score (partner→HMBOX1-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of telomere maintenance →	+0.063	+0.364	.001	<.001	3	13
ESCA	Negative regulation of mRNA metabolic process →	+0.058	+0.386	.001	<.001	3	13
ESCA	Regulation of mRNA processing →	+0.073	+0.394	<.001	<.001	3	13
ESCA	Response to UV-C →	+0.054	+0.435	.001	<.001	3	12
ESCA	Telomere maintenance via telomere lengthening →	+0.061	+0.415	.001	<.001	3	12
ESCA	Regulation of DNA recombination →	+0.055	+0.431	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,979 associations by consensus.

Regulation of telomere maintenance by HMBOX1-IT1 expression — ESCA

Explore this box plot interactively →