HMBOX1-IT1

Across TCGA pan-cancer cohorts, HMBOX1-IT1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated HMBOX1-IT1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HMBOX1-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HMBOX1-IT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

ACC, HNSC, and OV are the cancer types where HMBOX1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	IV	0.386	0.871	<.001	69	view →
HNSC	DFS	Tertile	IV	0.533	0.302	<.001	66	view →
OV	OS	Quartile	III,IV	0.457	0.327	.002	48	view →
THCA	OS	Tertile	IV	0.820	1.000	.001	42	view →
LAML	DFS	Tertile	All	0.674	0.424	.003	24	view →
KIRC	DFS	Quartile	III,IV	0.334	0.520	.010	23	view →
COAD	OS	Tertile	III,IV	0.135	0.569	.001	21	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	18	view →
UVM	OS	Tertile	III,IV	0.220	0.872	.025	18	view →
TGCT	DFS	Median	All	0.805	0.591	.011	14	view →
MESO	OS	Tertile	IV	0.204	0.652	.010	9	view →
READ	DFS	Tertile	IV	0.255	0.628	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

HMBOX1-IT1–ACC (OS)

Open the ACC breakdown →