HMBOX1-IT1

Across TCGA pan-cancer cohorts, HMBOX1-IT1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HMBOX1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HMBOX1-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMBOX1-IT1 is over-expressed in tumor.

KIRC, STAD, and HNSC are the cancer types where HMBOX1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMBOX1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.054	.008	4	view →
STAD	Female	All	+0.760	.022	3	view →
HNSC	Male	II,III,IV	+0.052	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

HMBOX1-IT1–KIRC

Open the KIRC breakdown →