HM13

Across TCGA patient cohorts, HM13 mutation is significantly associated with the RNA expression of many other genes, with 2,029 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HM13-associated genes across cancer lineages are MIR4433B, MCRIP2P2, and LIN7C. Each is linked with HM13 in more than 1 cancer types. Because this analysis shows association rather than direction, both HM13-to-partner and partner-to-HM13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4433B grouped by HM13-low versus HM13-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HM13→partner) and Y-score (partner→HM13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	MIR4433B →	+0.296	+5.068	<.001	.008	3	2
ESCA	MCRIP2P2 →	+0.171	+5.068	<.001	.008	3	2
UCEC	LIN7C →	+0.559	+2.960	<.001	<.001	3	2
UCEC	SCOC →	+0.475	+2.070	.007	.001	3	2
UCEC	PI4K2A →	+0.358	+3.040	<.001	<.001	3	2
UCEC	ZDHHC5 →	+0.270	+2.181	.007	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,029 associations by consensus.

MIR4433B by HM13 expression — ESCA

Explore this box plot interactively →