HM13

Across TCGA pan-cancer cohorts, HM13 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of HM13’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HM13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HM13 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where HM13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HM13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.967	<.001	12	view →
COAD	Male	IV	+1.565	<.001	11	view →
KIRP	All	II,III,IV	+1.366	<.001	11	view →
BLCA	Male	All	+1.019	<.001	11	view →
HNSC	All	All	+0.480	<.001	11	view →
LIHC	Female	II,III,IV	+1.431	<.001	9	view →
STAD	All	II,III,IV	+1.104	<.001	9	view →
LUAD	All	III,IV	+0.955	<.001	9	view →
LUSC	Male	All	+0.799	<.001	8	view →
READ	All	All	+1.233	<.001	7	view →
BRCA	All	III,IV	+1.079	<.001	6	view →
UCEC	All	All	+0.517	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

HM13–KIRC

Open the KIRC breakdown →