HLTF

Across TCGA patient cohorts, HLTF mutation is significantly associated with the RNA expression of many other genes, with 3,734 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLTF-associated genes across cancer lineages are GHITM, GLRX3, and DEPDC1. Each is linked with HLTF in more than 2 cancer types. Because this analysis shows association rather than direction, both HLTF-to-partner and partner-to-HLTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHITM grouped by HLTF-low versus HLTF-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLTF→partner) and Y-score (partner→HLTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GHITM →	+0.562	+3.471	<.001	.002	3	3
UCEC	GLRX3 →	+0.398	+1.528	.001	.002	3	3
UCEC	DEPDC1 →	+0.471	+1.496	.006	.002	3	3
UCEC	MTHFD2 →	+0.610	+1.823	<.001	.002	3	3
UCEC	AURKA →	+0.623	+1.906	<.001	<.001	3	3
UCEC	CWF19L1 →	+0.266	+2.457	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,734 associations by consensus.

GHITM by HLTF expression — LUSC

Explore this box plot interactively →