HLTF

Across TCGA patient cohorts, HLTF mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLTF-associated genes across cancer lineages are ASNS, Notch1, and Annexin-1. Each is linked with HLTF in more than 2 cancer types. Because this analysis shows association rather than direction, both HLTF-to-partner and partner-to-HLTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by HLTF-low versus HLTF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLTF→partner) and Y-score (partner→HLTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.382	+1.514	<.001	.014	3	3
UCEC	Notch1 →	+0.200	+2.676	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.508	+3.807	.001	<.001	3	2
UCEC	STAT5a →	+0.251	+1.201	.043	.028	3	2
UCEC	ATM →	-0.580	-2.986	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.265	-1.847	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ASNS by HLTF expression — UCEC

Explore this box plot interactively →