HLTF

Across TCGA cell cohorts, HLTF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,787 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLTF-associated GO terms across cancer lineages are Replication fork reversal, Chromosomal DNA methylation maintenance following DNA replication, and Protein localization to chromosome. Each is linked with HLTF in more than 16 cancer types. Because this analysis shows association rather than direction, both HLTF-to-partner and partner-to-HLTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Replication fork reversal grouped by HLTF-low versus HLTF-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLTF→partner) and Y-score (partner→HLTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Replication fork reversal →	+0.139	+1.191	<.001	<.001	3	16
OESOPHAGUS	Chromosomal DNA methylation maintenance following DNA replication →	+0.269	+1.206	<.001	<.001	2	17
UPPER_AERODIGESTIVE_TRACT	Protein localization to chromosome →	+0.122	+1.611	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Mitotic spindle organization →	+0.086	+1.431	.007	.004	2	15
BLOOD_Leukemia	Spindle assembly →	+0.070	+1.360	<.001	<.001	3	14
PANCREAS	Spindle organization →	+0.068	+1.320	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,787 associations by consensus.

Replication fork reversal by HLTF expression — OESOPHAGUS

Explore this box plot interactively →