HLTF

Across TCGA cell cohorts, HLTF mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HLTF-associated genes across cancer lineages are REG1B, TMEM95, and CEACAM3. Each is linked with HLTF in more than 1 cancer types. Because this analysis shows association rather than direction, both HLTF-to-partner and partner-to-HLTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by HLTF-low versus HLTF-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLTF→partner) and Y-score (partner→HLTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	REG1B →	+0.112	+5.415	<.001	.004	3	2
SKIN	TMEM95 →	+0.034	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CEACAM3 →	+0.617	+3.491	<.001	.008	3	1
LARGE_INTESTINE	B3GALT1 →	+0.399	+3.415	<.001	.009	3	1
LARGE_INTESTINE	SMIM33 →	+0.719	+3.648	<.001	.002	3	1
LARGE_INTESTINE	WSCD2 →	+0.118	+2.923	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

REG1B by HLTF expression — SKIN

Explore this box plot interactively →