HLTF

Across TCGA cell cohorts, HLTF mutation is significantly associated with the mutation status of many other genes, with 3,480 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HLTF-associated genes across cancer lineages are USP29, DACT1, and SUSD2. Each is linked with HLTF in more than 2 cancer types. Because this analysis shows association rather than direction, both HLTF-to-partner and partner-to-HLTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP29 grouped by HLTF-low versus HLTF-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLTF→partner) and Y-score (partner→HLTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	USP29 →	+5.297	+5.297	.004	.004	1	3
BREAST	DACT1 →	+5.297	+5.297	.004	.004	1	3
BREAST	SUSD2 →	+5.297	+5.297	.004	.004	1	3
SKIN	TAFA2 →	+4.824	+5.392	.004	.004	1	3
LARGE_INTESTINE	MCF2 →	+2.807	+3.321	<.001	<.001	1	3
BREAST	PDK4 →	+4.297	+4.857	.009	.009	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,480 associations by consensus.

USP29 by HLTF expression — BREAST

Explore this box plot interactively →