HLCS

Across TCGA patient cohorts, HLCS protein abundance is significantly associated with the RNA expression of many other genes, with 6,598 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLCS-associated genes across cancer lineages are P2RX1, CFAP47, and TTC3. Each is linked with HLCS in more than 3 cancer types. Because this analysis shows association rather than direction, both HLCS-to-partner and partner-to-HLCS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLCS versus P2RX1 in BRCA, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLCS→partner) and Y-score (partner→HLCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	P2RX1 →	-0.615	-0.271	.001	<.001	3	4
CCRCC	CFAP47 →	+1.224	+0.155	<.001	.002	3	4
BRCA	TTC3 →	+0.557	+0.245	<.001	<.001	3	4
HNSC	RNA5SP491 →	+0.824	+0.272	.001	<.001	3	4
LSCC	DONSON →	+0.479	+0.215	<.001	<.001	3	3
HNSC	NUDT6 →	+0.475	+0.261	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,598 associations by consensus.

HLCS vs P2RX1 — BRCA

Explore this scatter interactively →