HLCS

Across TCGA pan-cancer cohorts, HLCS RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HLCS data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher HLCS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HLCS expression acts as an unfavorable survival marker, although some lineages such as HNSC and READ show a favorable association.

UVM, LGG, and MESO are the cancer types where HLCS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.409	0.750	<.001	121	view →
LGG	OS	Median	All	0.711	0.911	<.001	50	view →
MESO	DFS	Quartile	III,IV	0.228	0.469	<.001	42	view →
ACC	DFS	Median	All	0.227	0.666	<.001	37	view →
STAD	DFS	Quartile	IV	0.084	0.740	.002	30	view →
KICH	OS	Median	II,III,IV	0.813	0.966	.015	27	view →
HNSC	DFS	Quartile	All	0.836	0.638	<.001	23	view →
READ	OS	Tertile	III,IV	0.894	0.328	.009	22	view →
KIRC	DFS	Quartile	All	0.930	0.798	.010	18	view →
BRCA	OS	Tertile	II,III,IV	0.491	0.694	.002	14	view →
CHOL	DFS	Tertile	III,IV	0.163	0.751	.024	12	view →
DLBC	DFS	Quartile	All	0.648	1.000	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HLCS–UVM (DFS)

Open the UVM breakdown →